[HTML][HTML] Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14
SM Palmer, W Klimecki, L Yu, NL Reinsmoen… - American Journal of …, 2007 - Elsevier
We have developed the hypothesis that genetic polymorphisms which alter the expression
or function of innate immune receptors contribute to the marked interindividual differences in
the onset and severity of lung transplant rejection. In this analysis, we considered the effects
of a common promotor polymorphism of the lipopolysaccharide receptor CD14 associated
with increased transcriptional activity upon the development of posttransplant rejection and
graft survival. Genotyping was performed in 226 lung transplant recipients well …
or function of innate immune receptors contribute to the marked interindividual differences in
the onset and severity of lung transplant rejection. In this analysis, we considered the effects
of a common promotor polymorphism of the lipopolysaccharide receptor CD14 associated
with increased transcriptional activity upon the development of posttransplant rejection and
graft survival. Genotyping was performed in 226 lung transplant recipients well …